Fatigue Damage–Resistant Physical Hydrogel Adhesion

Tough Wet Adhesion of Hydrogel

In nature, robust interfacial adhesion plays crucial roles in maintaining integration and functionality of various physiological structures including tendon and cartilage to bones and epidermis to dermis in mammalian skins. For instance, the bonding of tendon and cartilage to bone is extremely tough (e.g., interfacial toughness ~800 Jm 2 ), yet such tough interfaces have not been achieved betwe...

Tailoring hydrogel adhesion to polydimethylsiloxane substrates using polysaccharide glue.

With the emergence of microscale biotechnology, such as biomicroelectromechanical systems (“Bio-MEMS”) and microfluidic-based microchips for sensing and diagnostics, polydimethylsiloxane (PDMS)-based elastomers have become very popular materials. PDMS elastomers possess several features that are well suited for these applications: mechanical stability and elasticity, chemical inertness, optical...

Biocompatible Anti-adhesion Effect of Biodissociated Phospholipid Polymer Hydrogel

Biocompatible Anti-adhesion Effect of Biodissociated Phospholipid Polymer Hydrogel Noriyuki Ishiyama1, Toru Moro1, Toshiki Miura1, Takashi Ohe4,1, Shozo Itoh1, Tomohiro Konno2, Mizuna Yoshikawa3, Tadashi Ohyama3, Kazuhiko Ishihara2, Kozo Nakamura1, Hiroshi Kawaguchi1 1Orthopaedic Surgery, School of Medicine, The University of Tokyo, Tokyo, Japan; 2Materials Engineering, School of Engineering, T...

Hydrogel Contact Lenses Surface Roughness and Bacterial Adhesion

Intracerebral Implantation of Hydrogel-Coupled Adhesion Peptides: Tissue Reaction

Arg-Gly-Asp peptides (RGD) were synthesized and chemically coupled to the bulk of N-(2-hydroxypropyl) methacrylamide-based polymer hydrogels. Fourier Transform Infrared Spectroscopy (FTIR) and amino acid analysis confirmed the peptide coupling to the polymer. Activated and control (unmodified) polymer matrices were stereotaxically implanted in the striata of rat brains, and two months later the...